Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer
- 8 June 2012
- journal article
- review article
- Published by Taylor & Francis Ltd in Pharmaceutical Development and Technology
- Vol. 17 (5), 521-540
- https://doi.org/10.3109/10837450.2012.696268
Abstract
Colorectal cancer (CRC) is the third most common cause of cancer-related death in both men and women. Often, surgical intervention remains the choice in treating CRC. Traditional dosage forms used for treating CRC deliver drug to wanted as well as unwanted sites of drug action resulting in several adverse side effects. Targeted oral drug delivery systems are being investigated to target and deliver chemotherapeutic and chemopreventive agents directly to colon and rectum. Site-specific delivery of a drug to colon increases its concentration at the target site, and thus requires a lower dose with reduced incidence of side effects. The major obstacle to be overcome for successful targeting of drug to colon through oral route is that drug absorption/degradation must be avoided in stomach and small intestine before the dosage form reaches colon. The review includes discussion of physiological factors that must be considered when targeting drugs directly to colorectal region, an outline on drugs used for treatment and prevention of CRC, and a brief description of various types of colon-targeted oral drug delivery systems. The focus is on the assessment of various formulation approaches being investigated for oral colon-specific delivery of drugs used in the treatment and prevention of CRC.Keywords
This publication has 195 references indexed in Scilit:
- Targeted Therapeutic Agents for Colorectal CancerGastroenterology Clinics of North America, 2010
- Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsClinics in Colon and Rectal Surgery, 2009
- The Role of Radiation Therapy for Colorectal CancerGastroenterology Clinics of North America, 2008
- Prevention of Colorectal Cancer: Diet, Chemoprevention, and LifestyleGastroenterology Clinics of North America, 2008
- Towards an oral influenza vaccine: Comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine modelVaccine, 2007
- Biodistribution and pharmacokinetics of colon-specific HPMA copolymer–9-aminocamptothecin conjugate in miceJournal of Controlled Release, 2007
- NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDsBiochemical and Biophysical Research Communications, 2004
- Focus on colon cancerCancer Cell, 2002
- The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous PolyposisThe New England Journal of Medicine, 2000
- Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic TherapyThe New England Journal of Medicine, 1981