Interleukin-8 and Interleukin-17 for Cancer
Open Access
- 7 March 2014
- journal article
- review article
- Published by Taylor & Francis Ltd in Cancer Investigation
- Vol. 32 (5), 197-205
- https://doi.org/10.3109/07357907.2014.898156
Abstract
Pro-inflammatory cytokines have been associated with chronic inflammation and inflammatory diseases. Increased levels of interleukins (ILs) have been associated with inflammatory disease exacerbation. ILs levels have been observed to be associated with advance stage cancer for several types of cancer and a poor prognostic maker for malignant disease. Moreover; increased levels of cytokines induce tumorigenesis. There are several paradigms such as the hepatocellular carcinoma induced from chronic inflammation of an underlying hepatitis. In the current review, we will focus on IL-8 and -17. These two ILs as in the case of others, induce neo-angiogenesis through activation of the vascular endothelial growth (VEGF) factor pathway. Additionally, they enhance the activity of matrix metalloproteinase-2 and -9 (MMP-2,-9) which in turn increase the metastatic activity of the underlying malignancy. Inhibition of cytokine production could be a potential treatment both for chronic inflammatory diseases and tumor modulation. Local microenvironment modulation could be applied in surgery resected patients as in the case of lung cancer in order to enhance the local immune activity.Keywords
This publication has 62 references indexed in Scilit:
- Luteolin 8-C-β-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-κB signaling in MCF-7 breast cancer cellsBiochimie, 2013
- Cytokine Patterns in Brain Tumour ProgressionMediators of Inflammation, 2013
- A Soft Coral Natural Product, 11-Episinulariolide Acetate, Inhibits Gene Expression of Cyclooxygenase-2 and Interleukin-8 through Attenuation of Calcium SignalingMolecules, 2013
- BATF regulates the development and function of IL-17 producing iNKT cellsBMC Immunology, 2013
- TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cellsMolecular Cancer, 2013
- Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8BMC Cancer, 2011
- Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patientsLung Cancer, 2010
- CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced AngiogenesisClinical Cancer Research, 2010
- IL-17 and Th17 CellsAnnual Review of Immunology, 2009
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)The Lancet, 2008