A novel precursor for the synthesis of C-nucleoside analogs. Synthesis of the C-nucleoside analogs of ribavirin, bredinin, and related compounds

Abstract

Synthesis of .beta.-D-ribofuranosyl-1-carboximidic acid methyl ester, a novel and versatile precursor for the synthesis of C-nucleoside analogs, was described. The utility of this precursor was illustrated by the preparation of several C-nucleoside analogs of 1,2,4-triazole and imidazole nucleosides, including the C-nucleoside analogs or ribavirin and bredinin. The synthesis and structural determination of an N-methyl derivative of the C-nucleoside analog of ribavirin were also described.