Cell (patho)physiology of magnesium
- 30 November 2007
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 114 (1), 27-35
- https://doi.org/10.1042/cs20070129
Abstract
There is an unsettled debate about the role of magnesium as a ‘chronic regulator’ of biological functions, as opposed to the well-known role for calcium as an ‘acute regulator’. New and old findings appear to delineate an increasingly complex and important role for magnesium in many cellular functions. This review summarizes the available evidence for a link between the regulation of intracellular magnesium availability and the control of cell growth, energy metabolism and death, both in healthy and diseased conditions. A comprehensive view is precluded by technical difficulties in tracing magnesium within a multicompartment and dynamic environment like the cell; nevertheless, the last few years has witnessed encouraging progress towards a better characterization of magnesium transport and its storage or mobilization inside the cell. The latest findings pave the road towards a new and deeper appreciation of magnesium homoeostasis and its role in the regulation of essential cell functions.Keywords
This publication has 69 references indexed in Scilit:
- Magnesium homeostasis in mammalian cellsFrontiers in Bioscience-Landmark, 2007
- Magnesium Deficiency Enhances Hydrogen Peroxide Production and Oxidative Damage in Chick Embryo Hepatocyte In VitroBioMetals, 2006
- Modulation of vascular smooth muscle cell growth by magnesium—role of mitogen—activated protein kinasesJournal of Cellular Physiology, 2003
- Isolation of Normal Epithelial Cells Adapted to Grow at Nonphysiological Concentration of MagnesiumBiochemical and Biophysical Research Communications, 2001
- The Human Mitochondrial Mrs2 Protein Functionally Substitutes for Its Yeast Homologue, A Candidate Magnesium TransporterGenomics, 2001
- Jumonji Is a Nuclear Protein That Participates in the Negative Regulation of Cell GrowthBiochemical and Biophysical Research Communications, 2000
- Mg2+ Control of Respiration in Isolated Rat Liver MitochondriaBiochemistry, 1996
- Magnesium deficiency in vitro enhances free radical‐induced intracellular oxidation and cytotoxicity in endothelial cellsFEBS Letters, 1992
- Regulation of Mg2+ uptake in isolated rat myocytes and hepatocytes by protein kinase CFEBS Letters, 1992
- The effect of magnesium on glycolysis of permeabilized Ehrlich Ascites tumor cellsBiochemical and Biophysical Research Communications, 1991