Plasma adiponectin is decreased in nonalcoholic fatty liver disease
- 1 January 2005
- journal article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 152 (1), 113-118
- https://doi.org/10.1530/eje.1.01821
Abstract
Objectives: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and is frequently associated with obesity and metabolic syndrome. The recently discovered hormone adiponectin is produced by adipose tissue, and low plasma adiponectin is considered a key factor in the development of the insulin resistance underlying metabolic syndrome. Animal studies suggest that adiponectin may protect against non-alcoholic steatohepatitis, but direct evidence in humans is lacking. We therefore conducted this study to assess the relationship between plasma adiponectin and nonalcoholic fatty liver disease to explore its role in the pathogenesis of this disease. Design and methods: We measured plasma adiponectin and anthropometric, biochemical, hormonal and metabolic correlates in a group of 17 NAFLD patients with diagnosis confirmed by biopsy, and 20 controls with comparable age, body-mass index and sex. Furthermore we compared plasma adiponectin in patients with simple steatosis and steatohepatitis. Results: Plasma adiponectin was significantly lower in NAFLD patients than controls (5.93±0.45 vs 15.67±1.60 ng/ml). Moreover, NAFLD patients were significantly more insulin resistant while having similar serum leptin. Adiponectin was similar in simple steatosis and in steatohepatitis (6.16±0.78 vs 5.69±0.49 ng/ml). An inverse correlation was observed between adiponectin and homeostatic model assessment (HOMA) of insulin resistance (P = 0.008), while adiponectin did not correlate with serum transaminases and lipid values. Conclusions: These data support a role for low circulating adiponectin in the pathogenesis of NAFLD and confirm the strict association between reduced adiponectin production by adipose tissue, NAFLD and insulin resistance.Keywords
This publication has 25 references indexed in Scilit:
- Adipocytokines and Insulin ResistanceJournal of Clinical Endocrinology & Metabolism, 2004
- Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progressionGastroenterology, 2003
- The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in miceJCI Insight, 2003
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndromeHepatology, 2003
- American Gastroenterological Association medical position statement: Nonalcoholic fatty liver diseaseGastroenterology, 2002
- Nonalcoholic Fatty Liver DiseaseNew England Journal of Medicine, 2002
- Nonalcoholic Fatty Liver DiseaseDiabetes, 2001
- Association of nonalcoholic fatty liver disease with insulin resistanceAmerican Journal Of Medicine, 1999
- Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological LesionsAmerican Journal Of Gastroenterology, 1999