The Effects of Vitamins E and C on Fracture Healing in Rats
- 25 June 2002
- journal article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 30 (3), 309-313
- https://doi.org/10.1177/147323000203000312
Abstract
Forty-eight rats were divided into four groups of 12. For 3 days, each group received the following vitamins in once-daily doses: group 1, vitamin E only; group 2, vitamin C only; group 3, vitamins E and C; and group 4, no treatment (control). The right tibia of each rat was fractured on day 4; the rats then received the same regimen three times a week (once-daily doses) until day 21. Fracture healing was evaluated radiologically by measuring the callus indices, and histologically by a 5-point grading scale. On days 14 and 21, the callus index values in group 2 were statistically higher than those in the other groups. Histological evaluation scores in group 2 were the highest overall, and group 3 scores were higher than those in groups 1 and 4. These findings indicate that vitamin C accelerates fracture healing, vitamin E does not exert a marked effect on this process, and vitamins E and C in combination do not have a synergistic impact on fracture healing.Keywords
This publication has 12 references indexed in Scilit:
- The Role of Ascorbic Acid in Mesenchymal DifferentiationNutrition Reviews, 2009
- Ascorbic acid-induced chondrocyte terminal differentiation: the role of the extracellular matrix and 1,25-dihydroxyvitamin DEuropean Journal of Cell Biology, 1998
- Impaired Expression of Noncollagenous Bone Matrix Protein mRNAs During Fracture Healing in Ascorbic Acid-Deficient RatsJournal of Bone and Mineral Research, 1998
- Vitamin C Supplementation Restores the Impaired Vitamin E Status of Guinea Pigs Fed Oxidized Frying Oil ,Journal of Nutrition, 1998
- Interaction among vitamin C, vitamin E, and beta-caroteneThe American Journal of Clinical Nutrition, 1995
- Oxygen-free radicals impair fracture healing in ratsActa Orthopaedica, 1995
- Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cellsJournal of Bone and Mineral Research, 1992
- Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-El cellsJournal of Bone and Mineral Research, 1991
- Synergistic Action of Vitamin E and Vitamin C in Vivo Using a New Mutant of Wistar-Strain Rats, ODS, Unable to Synthesize Vitamin C.Journal of Nutritional Science and Vitaminology, 1991
- Indomethacin and Aspirin: Effect of Nonsteroidal Anti-Inflammatory Agents on the Rate of Fracture Repair in the RatActa Orthopaedica, 1980