Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Top Cited Papers
- 30 November 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 45 (12), 1452-U206
- https://doi.org/10.1038/ng.2802
Abstract
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 x 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.This publication has 52 references indexed in Scilit:
- GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s DiseaseNeuron, 2013
- SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and CaucasiansPLOS ONE, 2013
- TREM2 Variants in Alzheimer's DiseaseNew England Journal of Medicine, 2013
- Variant ofTREM2Associated with the Risk of Alzheimer's DiseaseNew England Journal of Medicine, 2013
- Genetic insights in Alzheimer's diseaseThe Lancet Neurology, 2013
- Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signalingCellular Signalling, 2012
- CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase CblThe Journal of Immunology, 2012
- In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal SurvivalPLOS ONE, 2012
- High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer diseaseMolecular Psychiatry, 2012
- Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sitesMolecular Psychiatry, 2011