The clinical utility of testicular cancer risk loci
Open Access
- 1 January 2011
- journal article
- editorial
- Published by Springer Science and Business Media LLC in Genome Medicine
- Vol. 3 (1), 1
- https://doi.org/10.1186/gm215
Abstract
Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care.Keywords
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