Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
Top Cited Papers
- 6 April 2008
- journal article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 14 (5), 504-506
- https://doi.org/10.1038/nm1747
Abstract
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.Keywords
This publication has 11 references indexed in Scilit:
- Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Neurobiology of Disease, 2007
- Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's diseaseBrain, 2005
- Lewy-body formation is an aggresome-related process: a hypothesisThe Lancet Neurology, 2004
- A double‐blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseAnnals of Neurology, 2003
- Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 2003
- Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's DiseaseThe New England Journal of Medicine, 2001
- Dopamine release from nigral transplants visualized in vivo in a Parkinson's patientNature Neuroscience, 1999
- Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studiesJournal of Comparative Neurology, 1996
- Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's DiseaseThe New England Journal of Medicine, 1995
- Transplantation of fetal dopamine neurons in Parkinson's disease: PET {18F}6‐L‐fluorodopa studies in two patients with putaminal implantsAnnals of Neurology, 1992