Acquired Immune Demyelinating Neuropathies
- 1 October 2014
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in CONTINUUM: Lifelong Learning in Neurology
- Vol. 20, 1241-1260
- https://doi.org/10.1212/01.con.0000455883.91426.12
Abstract
Acquired immune demyelinating neuropathies refer to a group of disorders that share overlapping sensory, motor, and autonomic clinical, laboratory, and electrodiagnostic features. It is important to recognize acquired immune demyelinating neuropathies as they are generally responsive to immunosuppressive or immunomodulatory therapies.This article reviews recently developed early prognostic tools in Guillain-Barré syndrome and discusses the evolving understanding of chronic demyelinating phenotypes with differing treatment responsiveness.While weakness and numbness progress over 2 to 4 weeks in Guillain-Barré syndrome, they continue to evolve beyond 8 weeks in chronic inflammatory demyelinating polyradiculoneuropathy and over 4 to 8 weeks in subacute inflammatory demyelinating polyradiculoneuropathy. Acquired immune demyelinating neuropathies present uncommonly as variants with predominance of ocular, bulbar, sensory, autonomic, or motor manifestations in addition to regional variants, such as paraparetic acquired immune demyelinating neuropathies. Establishing the correct diagnosis is important as these immune disorders differ in response to corticosteroids and other immunosuppressive therapies.Keywords
This publication has 33 references indexed in Scilit:
- Guillain-Barré Syndrome and VariantsNeurologic Clinics, 2013
- Early recognition of poor prognosis in Guillain-Barré syndromeNeurology, 2011
- Pharmacokinetics of intravenous immunoglobulin and outcome in Guillain‐Barré syndromeAnnals of Neurology, 2009
- The Epidemiology of Guillain-Barré Syndrome WorldwideNeuroepidemiology, 2008
- Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrumZeitschrift für Neurologie, 2008
- Immunotherapy for Guillain-Barre syndrome: a systematic reviewBrain, 2007
- Long-term outcome in patients with Guillain–Barré syndrome requiring mechanical ventilationNeurology, 2000
- A Randomized Trial Comparing Intravenous Immune Globulin and Plasma Exchange in Guillain–Barré SyndromeThe New England Journal of Medicine, 1992
- Plasmapheresis and acute Guillain‐Barre syndromeNeurology, 1985
- Sequential electrodiagnostic abnormalities in acute inflammatory demyelinating polyradiculoneuropathyMuscle & Nerve, 1985