Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A.
Open Access
- 1 June 1988
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 167 (6), 1945-1950
- https://doi.org/10.1084/jem.167.6.1945
Abstract
We present a model in which animals are passively immunized at a mucosal site, allowing one to evaluate immunological protection at the mucosal level only. Affinity-purified, anti-M protein sIgA administered intranasally protected mice against systemic infection after intranasal challenge with group A streptococci. In contrast, anti-M protein serum Ig administered intranasally was not protective at this site, although it neutralized the antiphagocytic property of M protein and promoted phagocytosis. Protection by sIgA occurred despite the lower immunoreactivity of sIgA to purified M protein compared with serum Ig. The data suggest that sIgA can protect at the mucosa and may preclude the need for opsonic IgG in preventing streptococcal infection.Keywords
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