A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response
Open Access
- 1 November 2008
- journal article
- review article
- Published by SAGE Publications in Journal of Diabetes Science and Technology
- Vol. 2 (6), 1003-1015
- https://doi.org/10.1177/193229680800200610
Abstract
In recent years, a variety of devices (drug-eluting stents, artificial organs, biosensors, catheters, scaffolds for tissue engineering, heart valves, etc.) have been developed for implantation into patients. However, when such devices are implanted into the body, the body can react to these in a number of different ways. These reactions can result in an unexpected risk for patients. Therefore, it is important to assess and optimize the biocompatibility of implantable devices. To date, numerous strategies have been investigated to overcome body reactions induced by the implantation of devices. This review focuses on the foreign body response and the approaches that have been taken to overcome this. The biological response following device implantation and the methods for biocompatibility evaluation are summarized. Then the risks of implantable devices and the challenges to overcome these problems are introduced. Specifically, the challenges used to overcome the functional loss of glucose sensors, restenosis after stent implantation, and calcification induced by implantable devices are discussed.Keywords
This publication has 136 references indexed in Scilit:
- Foreign body reaction to biomaterialsSeminars in Immunology, 2008
- In vitro, in vivo and post explantation testing of glucose-detecting biosensors: Current methods and recommendationsBiomaterials, 2007
- Calcification of Tissue Heart Valve Substitutes: Progress Toward Understanding and PreventionThe Annals of Thoracic Surgery, 2005
- Can Sensors Make a Home in the Body?Science, 2002
- Bioartificial Organs in the Twenty‐first CenturyAnnals of the New York Academy of Sciences, 2001
- Lifespan of subcutaneous glucose sensors and their performances during dynamic glycaemia changes in ratsJournal of Biomedical Engineering, 1993
- Subcutaneous glucose monitoring by means of electrochemical sensors: fiction or reality?Journal of Biomedical Engineering, 1992
- Characterization and anticalcification effects of implantable polyurethane matrices containing amorphous dispersion of bisphosphonic acidClinical Materials, 1991
- Fibrogenic cytokines: the role of immune mediators in the development of scar tissueImmunology Today, 1991
- Monocytes and MacrophagesThe New England Journal of Medicine, 1988