Super-Resolution Fluorescence Microscopy
Top Cited Papers
- 1 June 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 78 (1), 993-1016
- https://doi.org/10.1146/annurev.biochem.77.061906.092014
Abstract
Achieving a spatial resolution that is not limited by the diffraction of light, recent developments of super-resolution fluorescence microscopy techniques allow the observation of many biological structures not resolvable in conventional fluorescence microscopy. New advances in these techniques now give them the ability to image three-dimensional (3D) structures, measure interactions by multicolor colocalization, and record dynamic processes in living cells at the nanometer scale. It is anticipated that super-resolution fluorescence microscopy will become a widely used tool for cell and tissue imaging to provide previously unobserved details of biological structures and processes.Keywords
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