Current status of severe fever with thrombocytopenia syndrome in China
- 27 February 2017
- journal article
- review article
- Published by Elsevier BV in Virologica Sinica
- Vol. 32 (1), 51-62
- https://doi.org/10.1007/s12250-016-3931-1
Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity, clinical features, and diagnostics of SFTSV in China. From 2010 to October 2016, SFTS cases were reported in 23 provinces of China, with increased numbers yearly. Infection and death cases are mainly found in central China, where the Haemaphysalis longicornis ticks are spread. The national average mortality rate of SFTS infection was 5.3%, with higher risk to elder people. The main epidemic period was from May to July, with a peak in May. Thus, SFTS reminds a significant public health problem, and development of prophylactic vaccines and effective antiviral drugs will be highly needed.Keywords
This publication has 64 references indexed in Scilit:
- Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal PeptidePLOS ONE, 2016
- Application of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for the detection of SFTSV-specific human IgG and IgM antibodies by indirect ELISAVirology Journal, 2015
- Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: A cohort study in ChinaVaccine, 2015
- Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, ChinaPLoS Neglected Tropical Diseases, 2014
- The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in JapanThe Journal of Infectious Diseases, 2013
- An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSVScience China Life Sciences, 2013
- Development and application of a one‐step real‐time RT‐PCR using a minor‐groove‐binding probe for the detection of a novel bunyavirus in clinical specimensJournal of Medical Virology, 2012
- A Family Cluster of Infections by a Newly Recognized Bunyavirus in Eastern China, 2007: Further Evidence of Person-to-Person TransmissionClinical Infectious Diseases, 2011
- Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assayJournal of Clinical Virology, 2011
- Rival Teams Identify a Virus Behind Deaths in Central ChinaScience, 2010