Fluorescein sodium-guided surgery in glioblastoma multiforme: a prospective evaluation
- 1 January 2008
- journal article
- research article
- Published by Informa UK Limited in British Journal Of Neurosurgery
- Vol. 22 (1), 99-103
- https://doi.org/10.1080/02688690701765524
Abstract
We have evaluated the influence of fluorescein-guided resection on gross total resection (GTR) and survival in a series of patients with GBM. Group 1 consisted of 47 patients given fluorescein and group 2 comprised 33 patients, on whom fluorescein was not used. Median survival time was 43.9 weeks in the patients given fluorescein and was 41.8 weeks in the non-fluorescein group. There was no statistically significant difference in survival between the two groups. However, the extent of resection had a powerful influence on the median survival time. Survival was 34.3 weeks after partial resection and 46.5 after GTR. Our data shows that the use of fluorescein injection is a simple procedure, which allows a significant increase in the number of patients having GTR (83 vs. 55%). Our findings are similar to a recently published multicentre Phase III randomized trial in which 5-aminolevulinic acid was used to facilitate resection of malignant glioma.Keywords
This publication has 14 references indexed in Scilit:
- Prognosis factors of survival time in patients with glioblastoma multiforme: a multivariate analysis of 340 patientsActa Neurochirurgica, 2007
- Survival of glioblastoma patients related to presenting symptoms, brain site and treatment variablesJournal of Clinical Neuroscience, 2006
- Effectiveness of neuronavigation in resecting solitary intracerebral contrast-enhancing tumors: a randomized controlled trialJournal of Neurosurgery, 2006
- Glioblastoma multiforme—report of 267 cases treated at a single institutionSurgical Neurology, 2005
- Glioblastoma cells release factors that disrupt blood-brain barrier featuresActa Neuropathologica, 2004
- Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodiumJournal of Neurosurgery, 2003
- A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survivalJournal of Neurosurgery, 2001
- Fluorescence-guided resection of glioblastoma multiforme utilizing 5-ALA-induced porphyrins: a prospective study in 52 consecutive patientsJournal of Neurosurgery, 2000
- Early Postoperative Magnetic Resonance Imaging after Resection of Malignant GliomaNeurosurgery, 1994
- Epidemiology of brain tumorsNeurology, 1985