Importance of appropriate initial antibiotic therapy and de-escalation in the treatment of nosocomial pneumonia
Open Access
- 1 August 2007
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Review
- Vol. 16 (103), 33-39
- https://doi.org/10.1183/09059180.00010302
Abstract
Inappropriate initial antibiotic therapy in nosocomial pneumonia is associated with higher mortality, longer hospital stays and increased healthcare costs. The key pathogens associated with these adverse outcomes include Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii.Keywords
This publication has 17 references indexed in Scilit:
- De-escalation in lower respiratory tract infectionsCurrent Opinion in Pulmonary Medicine, 2006
- Tigecycline: A glycylcycline antimicrobial agentClinical Therapeutics, 2006
- Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with β-lactam antibioticsToxicology, 2006
- Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapyCritical Care Medicine, 2006
- Bloodstream Infections Caused by Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae : Risk Factors, Molecular Epidemiology, and Clinical OutcomeAntimicrobial Agents and Chemotherapy, 2006
- Extended-spectrum β-lactamases: A challenge for clinical microbiologists and infection control specialistsAmerican Journal of Infection Control, 2005
- National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004American Journal of Infection Control, 2004
- Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection PotentialAntimicrobial Agents and Chemotherapy, 2004
- Pneumonia in the intensive care unitCritical Care Medicine, 2003
- Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unitIntensive Care Medicine, 1996