Depression Scores Associate With Chronotype and Social Jetlag in a Rural Population
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- 6 September 2011
- journal article
- research article
- Published by Taylor & Francis Ltd in Chronobiology International
- Vol. 28 (9), 771-778
- https://doi.org/10.3109/07420528.2011.602445
Abstract
In public health, mood disorders are among the most important mental impairments. Patients with depressive episodes exhibit daily mood variations, abnormal patterns in sleep-wake behavior, and in the daily rhythms of several endocrine-metabolic parameters. Although the relationship between the sleep/circadian processes and mood disorders is poorly understood, clock-related therapies, such as light therapy, sleep deprivation, and rigid sleep schedules, have been shown to be effective treatments. Several studies investigated the relationship between circadian phenotype (chronotype) and depression. These focused mainly on urban populations and assessed diurnal preferences (Morningness-Eveningness score) rather than the actual timing of sleep and activity. Here, we used the Beck Depression Inventory (BDI) in an essentially rural population (N = 4051), and investigated its relation to circadian phenotype (chronotype and social jetlag), assessed with the Munich Chronotype Questionnaire (MCTQ). In our study design, we (i) normalized both chronotype and BDI scores for age and sex (MSFsas and BDIas, respectively); (ii) calculated individual social jetlag (misalignment of the biological and social time); and (iii) investigated the relationship between circadian phenotypes and BDI scores in a population homogeneous in respect to culture, socioeconomic factors, and daily light exposure. A 15.65% (N = 634) of the participants showed mild to severe depressive BDI scores. Late chronotypes had a higher BDIas than intermediate and early types, which was independent of whether or not the participants were smokers. Both chronotype and BDIas correlated positively with social jetlag. BDIas was significantly higher in subjects with >2 h of social jetlag than in the rest of the population—again independent of smoking status. We also compared chronotype and social jetlag distributions between BDI categories (no symptoms, minimal symptoms, and mild to severe symptoms of depression) separately for men and women and for four age groups; specifically in the age group 31–40 yrs, subjects with mild to severe BDI scores were significantly later chronotypes and suffered from higher social jetlag. Our results indicate that misalignment of circadian and social time may be a risk factor for developing depression, especially in 31- to 40-yr-olds. These relationships should be further investigated in longitudinal studies to reveal if reduction of social jetlag should be part of prevention strategies. (Author correspondence: karla. allebrandt@med. uni-muenchen. de )Keywords
This publication has 48 references indexed in Scilit:
- ETHICS AND METHODS FOR BIOLOGICAL RHYTHM RESEARCH ON ANIMALS AND HUMAN BEINGSChronobiology International, 2010
- Obeying the clock yields benefits for metabolismProceedings of the National Academy of Sciences of the United States of America, 2009
- Adverse metabolic and cardiovascular consequences of circadian misalignmentProceedings of the National Academy of Sciences of the United States of America, 2009
- Chronotype and Body Composition in Bipolar DisorderChronobiology International, 2009
- Depression and Pesticide Exposures among Private Pesticide Applicators Enrolled in the Agricultural Health StudyEnvironmental Health Perspectives, 2008
- An animated depiction of major depression epidemiologyBMC Psychiatry, 2007
- Circadian genes, rhythms and the biology of mood disordersPharmacology & Therapeutics, 2007
- The human circadian clock entrains to sun timeCurrent Biology, 2007
- The circadian basis of winter depressionProceedings of the National Academy of Sciences of the United States of America, 2006
- Body temperature and diurnal type in women with seasonal affective disorderHealth Care for Women International, 1993