Use of sodium fluorescein in skull base tumors
Open Access
- 1 January 2010
- journal article
- Published by Scientific Scholar in Surgical Neurology International
- Vol. 1 (1), 70
- https://doi.org/10.4103/2152-7806.72247
Abstract
The authors present this study using sodium fluorescein (SF) to enhance skull base tumors by performing a quantitative digital analysis of tumor enhancement. The purpose of this study is to observe the grade of SF enhancement by the tumors. A prospective experiment within-subjects study design was performed which included six patients with skull base lesions. Digital pictures were taken before and after the SF systemic injection, using the same light source of the microsurgical field. The pictures were analyzed by computer software which calculated the wavelength (WL) of the SF pre- and post-injection. THE GROUP OF TUMORS WAS AS FOLLOWS: one vestibular schwannoma, three meningiomas, one craniopharyngioma and one pituitary adenoma. The SF enhancement in all tumors was strongly positive. The digital analysis of the pictures, considering the SF WL pre- and post-injection, presented P = 0.028 (Wilcoxon T test). The enhancement of the tumors by SF was consistent and evident. The introductory results suggest the possibility of using SF as an adjuvant tool for the skull base surgery. Further studies should test the clinical application of the SF in skull base tumors.Keywords
This publication has 36 references indexed in Scilit:
- Effects of ultraviolet radiation on human cutaneous nerve fibresCell Proliferation, 2009
- Development of a Fluorescein Operative Microscope for use During Malignant Glioma Surgery: A Technical Note and Preliminary ReportSurgical Neurology, 1998
- The natural history and growth rate of asymptomatic meningiomas: a review of 60 patientsJournal of Neurosurgery, 1995
- Surgery of tumors invading the cavernous sinusSurgical Neurology, 1988
- Petrosal Approach for Petroclival MeningiomasNeurosurgery, 1988
- Supraorbital-Pterional Approach to Skull Base LesionsNeurosurgery, 1987
- Anatomical Study of the Cavernous Sinus Emphasizing Operative Approaches and Related Vascular and Neural ReconstructionNeurosurgery, 1987
- Invading meningiomas of the sphenoid ridgeJournal of Neurosurgery, 1980
- Anatomy of the cavernous sinusJournal of Neurosurgery, 1976
- The Clinical Use of Fluorescein in NeurosurgeryJournal of Neurosurgery, 1948