Hypertension-related factors in patients with active and inactive acromegaly
Open Access
- 1 October 2011
- journal article
- Published by FapUNIFESP (SciELO) in Archives of Endocrinology and Metabolism
- Vol. 55 (7), 468-474
- https://doi.org/10.1590/s0004-27302011000700006
Abstract
INTRODUCTION: There are several complications of the cardiovascular system caused by acromegaly, especially hypertension. OBJECTIVES: To evaluate hypertension characteristics in patients with cured/controlled acromegaly and with the active disease. PATIENTS AND METHODS: Cross-sectional study of the follow-up of forty-four patients with acromegaly submitted to clinical evaluation, laboratory tests and cardiac ultrasound. Patients with cured and controlled disease were evaluated as one group, and individuals with active disease as second one. RESULTS: Forty-seven percent of the patients had active acromegaly, and these patients were younger and had lower blood pressure levels than subjects with controlled/cured disease. Hypertension was detected in 50% of patients. Subjects with active disease showed a positive correlation between IGF-1 and systolic and diastolic blood pressure levels (r = 0.48, p = 0.03; and r = 0.42, p = 0.07, respectively), and a positive correlation between IGF-1 and urinary albumin excretion (UAE) rates. In patients with active disease, IGF-1 was a predictor of systolic blood pressure, although it was not independent of UAE rate. For individuals with cured/controlled disease, waist circumference and triglycerides were the predictors associated with systolic and diastolic blood pressure. CONCLUSIONS: Our findings suggest that blood pressure levels in patients with active acromegaly are very similar, and depend on excess GH. However, once the disease becomes controlled and IGF-1 levels decrease, their blood pressure levels will depend on the other cardiovascular risk factors.Keywords
This publication has 31 references indexed in Scilit:
- Current thinking on the management of the acromegalic patientCurrent Opinion in Endocrinology, Diabetes and Obesity, 2007
- Microalbuminuria and Cardiovascular DiseaseClinical Journal of the American Society of Nephrology, 2007
- N-terminal pro-B-type natriuretic peptide in patients with growth hormone disturbancesClinical Endocrinology, 2007
- Alterações morfológicas e funcionais cardíacas e análise dos fatores determinantes de hipertrofia ventricular esquerda em 40 pacientes com acromegaliaArchives of Endocrinology and Metabolism, 2006
- Hypertension in acromegaly and in the normal population: prevalence and determinantsClinical Endocrinology, 2005
- Low-Grade Albuminuria and Incidence of Cardiovascular Disease Events in Nonhypertensive and Nondiabetic IndividualsCirculation, 2005
- Follow-up Report on the Diagnosis of Diabetes MellitusDiabetes Care, 2003
- Growth hormone and the heartClinical Endocrinology, 2001
- Prevalence of hypertension in acromegalic patients: clinical measurement versus 24-hour ambulatory blood pressure monitoringClinical Endocrinology, 1998
- Subclinical cardiac dysfunction in acromegaly: evidence for a specific disease of heart muscle.Heart, 1989