Increased risk of type 2 diabetes in antidepressant users: evidence from a 6‐year longitudinal study in the E3N cohort
- 16 June 2020
- journal article
- research article
- Published by Wiley in Diabetic Medicine
- Vol. 37 (11), 1866-1873
- https://doi.org/10.1111/dme.14345
Abstract
Aim To examine the association between antidepressant medication use and the risk of type 2 diabetes. Methods Data were obtained from the E3N study (Étude Épidémiologique de Femmes de la Mutuelle Générale de l'Éducation Nationale ), a French cohort study initiated in 1990, with questionnaire‐based follow‐up every 2 or 3 years. Exposure to antidepressants was obtained from drug reimbursement files available from 2004 onwards, and individually matched with questionnaire data. Cases of type 2 diabetes were identified from drug reimbursements. Cox proportional‐hazard regression models were used, with drug exposure considered as a time‐varying parameter. Results Of the 63 999 women who were free of drug‐treated type 2 diabetes at baseline in 2005, 1124 developed type 2 diabetes over the 6‐year follow‐up. Current use of antidepressants was associated with an increased risk of type 2 diabetes [hazard ratio 1.34 (95% CI 1.12, 1.61)] compared to non‐users. When the different types of antidepressants were considered, women who currently used selective serotonin reuptake inhibitors, imipramine‐type, 'other' or 'mixed' antidepressants had a 1.25‐fold (95% CI 0.99, 1.57), 1.66‐fold (95% CI 1.12, 2.46), 1.35‐fold (95% CI 1.00, 1.84) and 1.82‐fold (95% CI 0.85, 3.86) increase in risk of type 2 diabetes compared to non‐users, respectively. Conclusion Our study suggests a positive association between antidepressant use and the risk of type 2 diabetes among women. If this association is confirmed, screening and surveillance of glucose levels should be considered in the context of antidepressant therapy. Further studies assessing the underlying mechanisms of this association are needed. (ClinicalTrials.gov identifier: NCT03285230).Keywords
This publication has 31 references indexed in Scilit:
- Antidepressant use and new‐onset diabetes: a systematic review and meta‐analysisDiabetes/Metabolism Research and Reviews, 2013
- Antidepressant Use and Diabetes Mellitus Risk: A Meta-AnalysisKorean Journal of Family Medicine, 2013
- Antidepressant Medication Use and Risk of Hyperglycemia and Diabetes Mellitus—A Noncausal Association?Biological Psychiatry, 2011
- Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal WomenDiabetes Care, 2011
- Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adultsDiabetologia, 2011
- Antidepressant Medication Use, Weight Gain, and Risk of Type 2 DiabetesDiabetes Care, 2010
- Revisiting leptin’s role in obesity and weight lossJCI Insight, 2008
- Elevated Depression Symptoms, Antidepressant Medicine Use, and Risk of Developing Diabetes During the Diabetes Prevention ProgramDiabetes Care, 2008
- Partial residuals for the proportional hazards regression modelBiometrika, 1982
- The CES-D ScaleApplied Psychological Measurement, 1977