Y-Chromosome distribution within the geo-linguistic landscape of northwestern Russia
- 4 March 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Human Genetics
- Vol. 17 (10), 1260-1273
- https://doi.org/10.1038/ejhg.2009.6
Abstract
Populations of northeastern Europe and the Uralic mountain range are found in close geographic proximity, but they have been subject to different demographic histories. The current study attempts to better understand the genetic paternal relationships of ethnic groups residing in these regions. We have performed high-resolution haplotyping of 236 Y-chromosomes from populations in northwestern Russia and the Uralic mountains, and compared them to relevant previously published data. Haplotype variation and age estimation analyses using 15 Y-STR loci were conducted for samples within the N1b, N1c1 and R1a1 single-nucleotide polymorphism backgrounds. Our results suggest that although most genetic relationships throughout Eurasia are dependent on geographic proximity, members of the Uralic and Slavic linguistic families and subfamilies, yield significant correlations at both levels of comparison making it difficult to denote either linguistics or geographic proximity as the basis for their genetic substrata. Expansion times for haplogroup R1a1 date approximately to 18 000 YBP, and age estimates along with Network topology of populations found at opposite poles of its range (Eastern Europe and South Asia) indicate that two separate haplotypic foci exist within this haplogroup. Data based on haplogroup N1b challenge earlier findings and suggest that the mutation may have occurred in the Uralic range rather than in Siberia and much earlier than has been proposed (12.9±4.1 instead of 5.2±2.7 kya). In addition, age and variance estimates for haplogroup N1c1 suggest that populations from the western Urals may have been genetically influenced by a dispersal from northeastern Europe (eg, eastern Slavs) rather than the converse.Keywords
This publication has 55 references indexed in Scilit:
- Boundaries and clines in the West Eurasian Y‐chromosome landscape: Insights from the European part of RussiaAmerican Journal of Physical Anthropology, 2008
- Two Sources of the Russian Patrilineal Heritage in Their Eurasian ContextAmerican Journal of Human Genetics, 2008
- The Himalayas as a Directional Barrier to Gene FlowAmerican Journal of Human Genetics, 2007
- A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards EuropeEuropean Journal of Human Genetics, 2006
- Regional differences among the Finns: A Y-chromosomal perspectiveGene, 2006
- Contrasting patterns of Y-chromosome variation in South Siberian populations from Baikal and Altai-Sayan regionsHuman Genetics, 2005
- Genetic evidence for the Mongolian ancestry of KalmyksAmerican Journal of Physical Anthropology, 2005
- p53 polymorphisms in Russia and Belarus: correlation of the 2-1-1 haplotype frequency with longitudeMolecular Genetics and Genomics, 2005
- Y Chromosome and Mitochondrial DNA Variation in LithuaniansAnnals of Human Genetics, 2004
- Excavating Y-chromosome haplotype strata in AnatoliaHuman Genetics, 2004