Treatment-emergent adverse events associated with atypical antipsychotics
- 17 October 2011
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Pharmacotherapy
- Vol. 13 (11), 1587-1598
- https://doi.org/10.1517/14656566.2012.656590
Abstract
Introduction: Atypical antipsychotics provide broad-spectrum effectiveness for the acute and/or preventative treatment of disparate psychiatric disorders. Atypical antipsychotics offer improved efficacy in some psychopathological domains when compared with typical antipsychotics. Notwithstanding, atypicals are not a catholicon and are associated with clinically significant and treatment-limiting side effects (e.g., extrapyramidal symptoms and weight gain). Areas covered: This article reviews commonly encountered adverse events attributable to the use of atypical antipsychotic agents. This review aims to provide a current overview of common adverse events associated with atypical agents with a particular emphasis on adverse events that frequently lead to treatment discontinuation (e.g., changes in weight, metabolism, extrapyramidal side effects, neuroendocrine changes, blood dyscrasias, and cardiovascular toxicity). Expert opinion: Atypicals are not a catholicon and are associated with clinically significant and treatment-limiting side effects (e.g., extrapyramidal symptoms and weight gain). Improving the utility of these agents requires a familiarity and understanding of the heterogeneous tolerability and safety profiles of atypical agents as well as the therapeutic evidence for their efficacy.Keywords
This publication has 71 references indexed in Scilit:
- Aripiprazole for the treatment of irritability associated with autismExpert Opinion on Pharmacotherapy, 2011
- Increasing off‐label use of antipsychotic medications in the United States, 1995–2008Pharmacoepidemiology and Drug Safety, 2011
- Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: A pilot studyJournal of Psychiatric Research, 2010
- Number Needed to Treat to Harm for Discontinuation Due to Adverse Events in the Treatment of Bipolar Depression, Major Depressive Disorder, and Generalized Anxiety Disorder With Atypical AntipsychoticsBritish Journal of Psychology, 2010
- Long-term prognosis of diabetic patients with acute myocardial infarction in the era of acute revascularizationCardiovascular Diabetology, 2010
- Prevalence, Detection, and Management of the Metabolic Syndrome in Patients with Acute Myocardial Infarction: Role of an Obesity-Centric DefinitionCardiology Research and Practice, 2010
- Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac DeathThe New England Journal of Medicine, 2009
- Antipsychotic Therapy During Early and Late Pregnancy. A Systematic ReviewSchizophrenia Bulletin, 2008
- Antipsychotic-Induced HyperprolactinaemiaDrugs, 2004
- Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sciences, 2000