THETA-BURST STIMULATION: A NEW FORM OF TMS TREATMENT FOR DEPRESSION?
- 28 November 2014
- journal article
- review article
- Published by Hindawi Limited in Depression and Anxiety
- Vol. 32 (3), 182-192
- https://doi.org/10.1002/da.22335
Abstract
Major depressive disorder (MDD) is a common debilitating condition where only one third of patients achieve remission after the first antidepressant treatment. Inadequate efficacy and adverse effects of current treatment strategies call for more effective and tolerable treatment options. Transcranial magnetic stimulation (TMS) is a noninvasive approach to manipulate brain activity and alter cortical excitability. There has been more than 15 years of research on the use of repetitive form of TMS (rTMS) for the treatment of patients with depression, which has shown it to be an effective antidepressant treatment. Even though rTMS treatment has shown efficacy in treating depression, there is a high degree of interindividual variability in response. A newer form of rTMS protocol, known as theta‐burst stimulation (TBS), has been shown to produce similar if not greater effects on brain activity than standard rTMS. TBS protocols have a major advantage over standard rTMS approaches in their reduced administration duration. Conventional rTMS procedures last between 20 and 45 min, as compared to TBS paradigms that require 1 to 3 min of stimulation. Recently, a small number of studies have suggested that TBS has similar or better efficacy in treating depression compared to rTMS. Optimization, identification of response predictors, and clarification of neurobiological mechanisms of TBS is required if it is to be further developed as a less time intensive, safe, and effective treatment for MDD.Keywords
This publication has 101 references indexed in Scilit:
- Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortexExperimental Brain Research, 2011
- D2 Receptor Block Abolishes Theta Burst Stimulation-Induced Neuroplasticity in the Human Motor CortexNeuropsychopharmacology, 2011
- Safety of Theta Burst Transcranial Magnetic Stimulation: A Systematic Review of the LiteratureJournal Of Clinical Neurophysiology, 2011
- Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depressionDepression and Anxiety, 2010
- Simply longer is not better: reversal of theta burst after-effect with prolonged stimulationExperimental Brain Research, 2010
- Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and researchClinical Neurophysiology, 2009
- Report of seizure induced by continuous theta burst stimulationBrain Stimulation, 2009
- Theta burst stimulation‐induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set‐shifting task – a TMS–[11C]raclopride PET studyEuropean Journal of Neuroscience, 2008
- Theta burst stimulation induces after‐effects on contralateral primary motor cortex excitability in humansThe Journal of Physiology, 2008
- The physiological basis of the effects of intermittent theta burst stimulation of the human motor cortexThe Journal of Physiology, 2008