Audiogenic Seizure Susceptibility Induced in C57B1/6J Mice by Prior Auditory Exposure

Abstract

Pronounced susceptibility to audiogenic seizures was produced in highly resistant C57B1/6J mice after earlier exposure to a loud electric bell. There is a critical period between initial acoustic presentation and subsequent testing for susceptibility; this suggests a minimum age and a minimum lapse of time during which this "priming" is effective.