Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.
Open Access
- 1 April 1986
- journal article
- Published by Taylor & Francis Ltd in Molecular and Cellular Biology
- Vol. 6 (4), 1158-1163
- https://doi.org/10.1128/mcb.6.4.1158
Abstract
Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.Keywords
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