Respiratory syncytial virus vaccine development
- 1 October 2011
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Vaccines
- Vol. 10 (10), 1415-1433
- https://doi.org/10.1586/erv.11.120
Abstract
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract viral disease in infants and young children. Presently, there are no explicit recommendations for RSV treatment apart from supportive care. The virus is therefore responsible for an estimated 160,000 deaths per year worldwide. Despite half a century of dedicated research, there remains no licensed vaccine product. Herein are described past and current efforts to harness innate and adaptive immune potentials to combat RSV. A plethora of candidate vaccine products and strategies are reviewed. The development of a successful RSV vaccine may ultimately stem from attention to historical lessons, in concert with an integral partnering of immunology and virology research fields.Keywords
This publication has 215 references indexed in Scilit:
- A chemically defined production process for highly attenuated poxvirusesBiologicals, 2011
- The Role of Respiratory Virus Infections in Childhood Asthma InceptionImmunology and Allergy Clinics of North America, 2010
- The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic childrenJournal of Allergy and Clinical Immunology, 2010
- Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cellsHepatology, 2010
- The cotton rat model of respiratory viral infectionsBiologicals, 2009
- Respiratory viruses and eosinophils: Exploring the connectionsAntiviral Research, 2009
- Electrocardiography Screening for Cardiotoxicity after Modified Vaccinia Ankara VaccinationAmerican Journal Of Medicine, 2009
- The Biological Functions of T Helper 17 Cell Effector Cytokines in InflammationImmunity, 2008
- Rearrangement of Mouse Immunoglobulin Kappa Deleting Element Recombining Sequence Promotes Immune Tolerance and Lambda B Cell ProductionImmunity, 2008
- Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virusVaccine, 1990