A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
- 22 July 2002
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 99 (16), 10831-10836
- https://doi.org/10.1073/pnas.152343099
Abstract
Synapses in the brain are bidirectionally modifiable, but the routes of induction are diverse. In various experimental paradigms, N-methyl-d-aspartate receptor-dependent long-term depression and long-term potentiation have been induced selectively by varying the membrane potential of the postsynaptic neurons during presynaptic stimulation of a constant frequency, the rate of presynaptic stimulation, and the timing of pre- and postsynaptic action potentials. In this paper, we present a mathematical embodiment of bidirectional synaptic plasticity that is able to explain diverse induction protocols with a fixed set of parameters. The key assumptions and consequences of the model can be tested experimentally; further, the model provides the foundation for a unified theory of N-methyl-d-aspartate receptor-dependent synaptic plasticity.Keywords
This publication has 50 references indexed in Scilit:
- Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic PlasticityNeuron, 2001
- Intrinsic Stabilization of Output Rates by Spike-Based Hebbian LearningNeural Computation, 2001
- Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neuronsJournal Of Physiology-London, 2001
- An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of ratJournal Of Physiology-London, 2001
- Long‐term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice culturesJournal Of Physiology-London, 1998
- Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPsScience, 1997
- A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal NeuronsScience, 1997
- A critical period for long-term potentiation at thalamocortical synapsesNature, 1995
- Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiationTrends in Neurosciences, 1993
- Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortexNature, 1990