Maternal undernutrition during late pregnancy in sheep. Its relationship to maternal condition, gestation length, hepatic physiology and glucose metabolism
- 1 April 1996
- journal article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 75 (4), 593-605
- https://doi.org/10.1079/bjn19960162
Abstract
There is a paucity of information on the metabolic effects of undernutrition of the ewe carrying multiple fetuses in late pregnancy. In the present study the effects of induction of ketosis from 132 d gestation in ewes carrying twin fetuses were compared with a control group. The ewes were well fed up to 132 d. Ketotic ewes showed a loss of condition score from 3·7 (SE 0·11) at 130 d gestation to 3·0 (SE 0·15) 10 d later after clinical recovery, compared with control twin-pregnant ewes (P < 0·01). The weight loss during the same time period was from 70·6 (SE 2·7) kg at 130 d to 64·2 (SE 2·7) kg at 140 d gestation. As expected, both groups lost weight and condition score in the first 28 d of lactation. Induction of ketosis caused a significant shortening of the gestation period to 142·8 (SE 0·7) d compared with 150 (SE 0·4) d in normal twin-pregnant ewes (P < 0·001). Ewes with induced ketosis recovered clinically and showed a normal feed intake by 3·4 (SE 0·07) d; three required treatment. Induction of ketosis resulted in reduction of hepatic uptake of bromosulphthalein (P < 0·01) and its biliary excretion (P < 0·05), metabolic clearance rate (P < 0·001), fractional clearance (P < 0·001) and 15 and 30 min retention compared with control twin-pregnant ewes. Most values had returned to normal by the first week of lactation. It is thought that in human pregnancy similar changes in bromosulphthalein clearance may be related to reduced binding sites for bromosulphthalein in the liver caused by increased circulating oestrogens. Induction of ketosis resulted in a significant hypoglycaemic (P < 0·01), ketotic (P < 0·001) state compared with well-fed twin-pregnant ewes. These changes could be correlated with the severity of the clinical signs, together with a significant rise in plasma urea (P < 0·001) and NH3(P < 0·05) concentrations. Again, the return of most of these values to normal by the first week of lactation lends support to the reversibility of hepatic lesions caused by fatty infiltration of the liver. The seventy of this condition in naturally occurring cases suggests that factors other than undernutrition may be contributory, such as the general body condition of the ewe and glucose metabolism by the liver, including the conversion of propionate to glucose.Keywords
This publication has 17 references indexed in Scilit:
- Interactions between propionate and amino acid metabolism in isolated sheep hepatocytesBritish Journal of Nutrition, 1991
- Maternal undernutrition during mid-pregnancy in sheep. Placental size and its relationship to calcium transfer during late pregnancyBritish Journal of Nutrition, 1991
- Effects of Maternal Nutritional Status on Fetal and Placental Growth and on Fetal Urea Synthesis in SheepAustralian Journal of Biological Sciences, 1987
- Nutritional and Placental Determinants of Foetal Growth Rate in Sheep and Consequences for the Newborn LambBritish Veterinary Journal, 1983
- Umbilical uptake of amino acids in the unstressed fetal lamb.JCI Insight, 1976
- Quantitative aspects of hepatic and portal glucose metabolism and turnover in sheepAmerican Journal of Physiology-Legacy Content, 1970
- Metabolic and hormonal aspects of bovine ketosis and pregnancy toxaemia in the eweProceedings of the Nutrition Society, 1969
- Manual and AutoAnalyzer Methods for Measuring Blood Glucose Using Guaiacum and Glucose OxidaseProceedings of the Association of Clinical Biochemists, 1968
- Some Observations on Bovine AcetonaemiaResearch in Veterinary Science, 1960
- A RAPID AND PRECISE METHOD FOR THE DETERMINATION OF UREAJournal of Clinical Pathology, 1960