Understanding the diversification of HIV-1 groups M and O
- 20 August 2007
- journal article
- basic science
- Published by Ovid Technologies (Wolters Kluwer Health) in AIDS
- Vol. 21 (13), 1693-1700
- https://doi.org/10.1097/qad.0b013e32825eabd0
Abstract
Objective: To quantify the similarity (or lack of) between the phylogenetic substructure of HIV-1 groups O and M. Methods: Two phylogenetic tree statistics – the subtype diversity ratio (SDR) and the subtype diversity variance (SDV) – were used in conjunction with bootstrap replicates on gag, pol and env sequence alignments of group O and M strains. Randomly generated phylogenetic trees were used as a control. Results: We show that, as expected, the established global-group M subtypes have a high degree of phylogenetic symmetry in relation to each other in terms of inter- and intra-subtype diversification. They are significantly different from the substructure present amongst the random trees. To the contrary, the group O diversification does not display this highly symmetrical substructure and is not significantly different from the substructure present on randomly generated trees. Phylogenies comprised of group M strains from the epicentre of the HIV/AIDS pandemic, the Democratic Republic of Congo (DRC), exhibit a substructure more similar to group O than to global-group M. Conclusions: The substructure present within groups O and M is quantifiably different. The well defined clades, the subtypes that characterize group M diversification, are not present in group O or amongst group M strains from the DRC. The group M subtypes are thus unique and a signature of pandemic HIV-1.This publication has 30 references indexed in Scilit:
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