Impact of Oxidative Stress in Fetal Programming
Open Access
- 11 July 2012
- journal article
- review article
- Published by Hindawi Limited in Journal of Pregnancy
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/582748
Abstract
Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.Keywords
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