Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer
Open Access
- 1 January 2010
- journal article
- review article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 3 (3), 168-177
- https://doi.org/10.4161/oxim.3.3.12106
Abstract
Autophagy is a catalytic process of the bulk degradation of long-lived cellular components, ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known as autophagolysosomes. Autophagy serves many functions in the cell, including maintaining cellular homeostasis, a means of cell survival during stress (e.g., nutrient deprivation or starvation) or conversely as a mechanism for cell death. Increased reactive oxygen species (ROS) production and the resulting oxidative cell stress that occurs in many disease states has been shown to induce autophagy. The following review focuses on the roles that autophagy plays in response to the ROS generated in several diseases.Keywords
This publication has 100 references indexed in Scilit:
- Oxidative stress in prostate cancerCancer Letters, 2009
- The role of autophagy in the heartCell Death & Differentiation, 2008
- A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces AutophagyCancer Cell, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Small molecules enhance autophagy and reduce toxicity in Huntington's disease modelsNature Chemical Biology, 2007
- Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisCancer Cell, 2006
- Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceNature, 2006
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006
- ROS stress in cancer cells and therapeutic implicationsDrug Resistance Updates, 2004
- Influence of TOR kinase on lifespan in C. elegansNature, 2003