Alveolar rhabdomyosarcoma with the t(2;13): Cytogenetic findings and clinicopathologic correlations
- 1 January 1993
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 21 (2), 83-87
- https://doi.org/10.1002/mpo.2950210202
Abstract
We describe here the clinical and pathologic features associated with a specific translocation, t(2;13), in alveolar rhabdomyo-sarcoma. Tumor specimens from 14 patients with a t(2;13)-positive alveolar rhabdomyo-sarcoma were studied for cytogenetic-clinicopathologic correlations. Three patients had occult primary tumors; nine patients had primary tumors of the trunk (mediastinal, pelvic, or rectal). The presence of the t(2;13) was ascertained from examination of tumor involved bone marrow in ten patients who had widespread metastatic disease at the time of diagnosis. Marrow involvement was so extensive in three cases that they were initially diagnosed as acute leukemia. Response to therapy was poor, with only five patients achieving a complete response. Twelve patients have died of their disease at a median survival time of 6 months from diagnosis and one is living with recurrent disease; only one patient survives free of disease.Keywords
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