Toward a More Precise and Informative Nomenclature Describing Fetal and Neonatal Male Germ Cells in Rodents1
- 1 August 2013
- journal article
- review article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 89 (2), 47
- https://doi.org/10.1095/biolreprod.113.110502
Abstract
The germ cell lineages are among the best characterized of all cell lineages in mammals. This characterization includes precise nomenclature that distinguishes among numerous, often subtle, changes in function or morphology as development and differentiation of germ cells proceed to form the gametes. In male rodents, there are at least 41 distinct cell types that occur during progression through the male germ cell lineage that gives rise to spermatozoa. However, there is one period during male germ cell development—that which occurs immediately following the primordial germ cell stage and prior to the spermatogonial stage—for which the system of precise and informative cell type terminology is not adequate. Often, male germ cells during this period are referred to simply as “gonocytes.” However, this term is inadequate for multiple reasons, and it is suggested here that nomenclature originally proposed in the 1970s by Hilscher et al., which employs the terms M-, T1-, and T2-prospermatogonia, is preferable. In this Minireview, the history, proper utilization, and advantages of this terminology relative to that of the term gonocytes are described.Keywords
This publication has 107 references indexed in Scilit:
- The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ CellsMolecular Cell, 2012
- A unique regulatory phase of DNA methylation in the early mammalian embryoNature, 2012
- Primary epimutations introduced during intracytoplasmic sperm injection (ICSI) are corrected by germline-specific epigenetic reprogrammingProceedings of the National Academy of Sciences of the United States of America, 2012
- Epigenetic reprogramming in the germline: towards the ground state of the epigenomePhilosophical Transactions Of The Royal Society B-Biological Sciences, 2011
- Epigenetic modifications and self-renewal regulation of mouse germline stem cellsCell Research, 2011
- Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogrammingCell Research, 2011
- Interdependence of Platelet-Derived Growth Factor and Estrogen-Signaling Pathways in Inducing Neonatal Rat Testicular Gonocytes Proliferation1Biology of Reproduction, 2010
- Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bamDevelopmental Biology, 2008
- RNA expression microarray analysis in mouse prospermatogonia: Identification of candidate epigenetic modifiersDevelopmental Dynamics, 2008
- Erasure of methylation imprint at the promoter and CTCF-binding site upstream of H19 in human testicular germ cell tumors of adolescents indicate their fetal germ cell originOncogene, 2006