Carbon Monoxide in Sepsis
- 1 November 2007
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 9 (11), 2013-2026
- https://doi.org/10.1089/ars.2007.1762
Abstract
Despite modern practices in critical care medicine, sepsis or systemic inflammatory response syndrome remains a leading cause of morbidity and mortality in the intensive care unit. Thus, the need to identify new therapeutic tools for the treatment of sepsis is urgent. In this context, carbon monoxide has become a promising therapeutic molecule that can potentially prevent uncontrolled inflammation in sepsis. In humans, carbon monoxide arises endogenously from the degradation of heme by heme oxygenase enzymes. Both endogenously synthesized and exogenously applied carbon monoxide can exert antiinflammatory and antiapoptotic effects in cells and tissues. Based on these properties, carbon monoxide, when applied at low concentration, conferred protection in a variety of cellular and rodent models of sepsis, and furthermore reduced morbidity and mortality in vivo. Therefore, application of carbon monoxide may have a major impact on the future of sepsis treatment. This review summarizes evidence for salutary effects of carbon monoxide in sepsis of various organs, including lung, heart, kidney, liver, and intestine, and discusses the potential translation of the data into human clinical trials.Keywords
This publication has 133 references indexed in Scilit:
- Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid raftsThe Journal of Experimental Medicine, 2006
- Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathwayThe Journal of Experimental Medicine, 2005
- Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantationSurgery, 2005
- 30 some years of heme oxygenase: From a “molecular wrecking ball” to a “mesmerizing” trigger of cellular eventsBiochemical and Biophysical Research Communications, 2005
- Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivoJournal of Hepatology, 2004
- Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxideAmerican Journal of Physiology-Renal Physiology, 2004
- Differential Modulation by Exogenous Carbon Monoxide of TNF-α Stimulated Mitogen-Activated Protein Kinases in Rat Pulmonary Artery Endothelial CellsAntioxidants and Redox Signaling, 2002
- Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in miceNature Medicine, 2002
- A Heme Oxygenase Product, Presumably Carbon Monoxide, Mediates a Vasodepressor Function in RatsHypertension, 1995
- The formation of carbon monoxide during peroxidation of microsomal lipidsBiochemical and Biophysical Research Communications, 1976