The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis
Top Cited Papers
- 31 January 2018
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 51 (2), 1701953
- https://doi.org/10.1183/13993003.01953-2017
Abstract
Pseudomonas aeruginosa is responsible for chronic infection in many bronchiectasis patients but it is not known whether it is associated with worse clinical outcomes independent of the underlying severity of disease. This study analysed data from 2596 bronchiectasis patients included from 10 different bronchiectasis clinical centres across Europe and Israel, with a 5-year follow-up period. Prevalence of P. aeruginosa chronic infection and its independent impact on exacerbations, hospitalisations, quality of life and mortality was assessed. The prevalence of P. aeruginosa chronic infection was 15.0% (n=389). P. aeruginosa was associated with a higher mortality in a univariate analysis (hazard ratio (HR) 2.02; 95% (confidence interval) CI 1.53–2.66; pP. aeruginosa was independently associated with increased mortality only in patients with frequent exacerbations (two or more per year) (HR 2.03; 95% CI 1.36–3.03; p=0.001). An independent association with worse quality of life of 7.46 points (95% CI 2.93–12.00; p=0.001) was found in a multivariable linear regression. P. aeruginosa was therefore found to be independently associated with exacerbation frequency, hospital admissions and worse quality of life. Mortality was increased in patients with P. aeruginosa particularly in the presence of frequent exacerbations.Keywords
Funding Information
- Research grant from Grifols
This publication has 28 references indexed in Scilit:
- Clinical phenotypes in adult patients with bronchiectasisEuropean Respiratory Journal, 2016
- A Comprehensive Analysis of the Impact ofPseudomonas aeruginosaColonisation on Prognosis in Adult BronchiectasisAnnals of the American Thoracic Society, 2015
- Bacterial Adaptation during Chronic Respiratory InfectionsPathogens, 2015
- Non–Cystic Fibrosis BronchiectasisAmerican Journal of Respiratory and Critical Care Medicine, 2013
- Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasisMolecular Immunology, 2013
- Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non–Cystic Fibrosis BronchiectasisAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Immunity and bacterial colonisation in bronchiectasisThorax, 2011
- The effect of Pseudomonas aeruginosa on pulmonary function in patients with bronchiectasisEuropean Respiratory Journal, 2006
- Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosisPediatric Pulmonology, 2002
- Lung function in bronchiectasis: the influence of Pseudomonas aeruginosaEuropean Respiratory Journal, 1996