Cyanoacetanilide intermediates in heterocyclic synthesis. Part 7: preparation of some spiro[indoline-3,4′-pyridine] and chromeno[3,4-c]pyridine derivatives
Open Access
- 30 May 2013
- journal article
- research article
- Published by Walter de Gruyter GmbH in hc
- Vol. 19 (3), 195-200
- https://doi.org/10.1515/hc-2013-0032
Abstract
The reaction of cyanoacetanilide derivative 1 with some electrophiles was investigated. Treatment of compound 1 with 2-(2-oxoindol-3-ylidene)malononitrile (2a) under reflux in ethanol in the presence of piperidine afforded the spiro[indoline-3,4′-pyridine] derivative 3. Under similar conditions, condensation of compound 1 with the analog 2b yielded a spiroindole 4. Chromeno[3,4-c]pyridine derivative 6 was obtained by cyclization of chromene derivative 5 with ethyl cyanoacetate. In a similar manner, condensation of compound 5 with cylcohexanone under reflux in ethanol in the presence of sodium acetate furnished chromeno[3,4-c]quinoline derivative 7. Compound 1 was condensed with 2-hydroxy-1-naphthaldehyde to yield the benzo[f]chromeno derivative 8. Refluxing of benzochromene derivative 8 with ethyl cyanoacetate in ethanol in the presence of catalytic amount of piperidine produced benzo[f]chromeno[3,4-c]pyridine derivative 9. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data.This publication has 13 references indexed in Scilit:
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