Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages
Open Access
- 1 August 2015
- journal article
- Published by Elsevier BV in Online Journal of Public Health Informatics
- Vol. 290 (33), 20348-20359
- https://doi.org/10.1074/jbc.m115.662114
Abstract
No abstract availableKeywords
This publication has 45 references indexed in Scilit:
- The Ancient Drug Salicylate Directly Activates AMP-Activated Protein KinaseScience, 2012
- Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesityJCI Insight, 2011
- Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy statusDiabetologia, 2011
- Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic miceBritish Journal of Pharmacology, 2011
- AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer PartnerOnline Journal of Public Health Informatics, 2010
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesNature Immunology, 2010
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy stateJCI Insight, 2010
- How mitochondria produce reactive oxygen speciesBiochemical Journal, 2008
- Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein KinaseJournal of Biological Chemistry, 2007
- Role of AMP-activated protein kinase in mechanism of metformin actionJCI Insight, 2001