Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica
- 13 January 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 62 (1), 144-146
- https://doi.org/10.1212/wnl.62.1.144
Abstract
The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis (MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in patients with MS. The absence of the CSF IgG1 responses in the patients with RNMO may suggest less Th1 immunity and may also explain the rarity of oligoclonal IgG bands in patients with this disease.Keywords
This publication has 10 references indexed in Scilit:
- Pure optic-spinal form of multiple sclerosis in Japan.Brain, 2002
- A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis opticaBrain, 2002
- Oligoclonal bands and antibody responses in Multiple SclerosisZeitschrift für Neurologie, 2002
- Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosisJournal of Neuroimmunology, 2001
- Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signalingJournal of Neuroimmunology, 2001
- Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosisJournal of Neuroimmunology, 2000
- The clinical course of neuromyelitis optica (Devic’s syndrome)Neurology, 1999
- Adenosine triphosphate deficiencyNeurology, 1995
- Oligoclonal bands in cerebrospinal fluid detected by PhastSystem isoelectric focusingClinical Chemistry, 1990
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983