Acquired Echinocandin Resistance in a Candida krusei Isolate Due to Modification of Glucan Synthase
Open Access
- 1 May 2007
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (5), 1876-1878
- https://doi.org/10.1128/aac.00067-07
Abstract
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1 . The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.Keywords
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