Efficacy of Intravitreal Bevacizumab With Panretinal Photocoagulation Followed by Ahmed Valve Implantation in Neovascular Glaucoma
- 1 December 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Glaucoma
- Vol. 22 (9), 768-772
- https://doi.org/10.1097/ijg.0b013e318259aec4
Abstract
To establish the efficacy and safety of intravitreal bevacizumab (Avastin) with panretinal photocoagulation (PRP) followed by Ahmed valve implantation in the treatment of neovascular glaucoma (NVG). This prospective randomized study included 40 eyes of 40 patients with refractory NVG. Twenty eyes underwent Ahmed valve implantation with intravitreal bevacizumab (Avastin) (1.25 mg in 0.5 mL) and PRP and 20 eyes were managed by Ahmed valve and PRP (control group). The follow-up period was 18 months. Complete success was defined as an intraocular pressure ≤ 21 mm Hg. Qualified success was considered when the above criteria were fulfilled but with additions of antiglaucoma topical medical treatment. The results revealed 95% total success (75% complete success and 20% qualified success) in the first group in which Avastin-augmented Ahmed valve was performed compared with 50% total success in the control group in which Ahmed valve implantation was performed alone (25% complete success and 25% qualified success). Intravitreal bevacizumab (Avastin) with PRP followed by Ahmed valve implantation appears to be effective in the management of NVG.Keywords
This publication has 10 references indexed in Scilit:
- Neovascular glaucomaProgress in Retinal and Eye Research, 2007
- Intravitreal Bevacizumab (Avastin) Injection for Neovascular GlaucomaJournal of Glaucoma, 2007
- Bevacizumab (Avastin) for the treatment of neovascular glaucomaClinical & Experimental Ophthalmology, 2007
- Bevacizumab for Neovascular Ocular DiseasesAnnals of Pharmacotherapy, 2007
- RAPID IMPROVEMENT OF RUBEOSIS IRIDIS FROM A SINGLE BEVACIZUMAB (AVASTIN) INJECTIONRetina, 2006
- Intravitreal Bevacizumab in a Patient With Neovascular GlaucomaOphthalmic Surgery, Lasers and Imaging Retina, 2006
- Optical Coherence Tomography Findings After an Intravitreal Injection of Bevacizumab (Avastin®) for Neovascular Age-Related Macular DegenerationOphthalmic Surgery, Lasers and Imaging Retina, 2005
- Targeting angiogenesis, the underlying disorder in neovascular age-related macular degenerationCanadian Journal of Ophthalmology, 2005
- Intermediate-term clinical experience with the Ahmed Glaucoma Valve implantAmerican Journal of Ophthalmology, 1999
- Clinical Risk Factors for Failure in Glaucoma Tube SurgeryAmerican Journal of Ophthalmology, 1992