Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies
Open Access
- 11 August 2016
- journal article
- Published by American Society of Hematology in Blood
- Vol. 128 (6), 783-793
- https://doi.org/10.1182/blood-2015-10-676304
Abstract
Key Points Upon in vitro differentiation, iPSCs obtained from patients with SCID and OS show a similar block in T-cell development. Presence of unresolved single-strand DNA breaks in developing T cells from OS patient-derived iPSCs affects their differentiation.Keywords
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