Evaluation of two pediatric polymethyl pentene membrane oxygenators with pulsatile and non-pulsatile perfusion
- 19 January 2011
- journal article
- research article
- Published by SAGE Publications in Perfusion
- Vol. 26 (3), 229-237
- https://doi.org/10.1177/0267659110396116
Abstract
Objectives: This experiment sought to compare two polymethyl pentene (PMP) hollow-fiber membrane oxygenators: the Medos HILITE 2400 LT and the Maquet Quadrox-iD Pediatric in terms of transmembrane pressure gradients and hemodynamic energy preservation under both pulsatile and non-pulsatile conditions. Methods: A simulated pediatric extracorporeal life support (ECLS) circuit was used to test these two oxygenators. The circuit consisted of a roller pump, ¼ inch tubing for both arterial and venous lines, an oxygenator, and a venous reservoir served as a pseudo-patient. Three pressure transducers were placed upstream and downstream of the oxygenator and the distal arterial line. The experimental system was primed with lactated Ringer’s solution and packed human red blood cells to maintain a hematocrit of 40%.The total volume was 600 ml, including the 350 ml volume of the pseudo-patient.The tests were performed at six flow rates (250, 500, 750, 1000, 1250, 1500 ml/min) and three distal arterial line pressures (MAP) (60, 80, 100 mmHg), under both pulsatile and non-pulsatile perfusion modes.The temperature was kept constant at 37°C for all tests. Results: Both oxygenators had adequate performances in pressure drop and hemodynamic energy preservation. There were no significant differences between pre- and post-oxygenators for mean pressure (MP), energy equivalent pressure (EEP) and total hemodynamic energy (THE). During the pulsatile perfusion mode, the HILITE 2400 LT retained a greater percentage of surplus hemodynamic energy (SHE) across the oxygenator. Conclusions: Both the Quadrox-iD Pediatric and HILITE 2400LT PMP membrane oxygenators are suitable for pediatric ECLS therapy under both non-pulsatile and pulsatile perfusion. An optimized combination of flow rate and MAP should be achieved in order to deliver the maximal pulsatile energy in the extracorporeal circuit.Keywords
This publication has 13 references indexed in Scilit:
- Evolution of the Extracorporeal Life Support CircuitryArtificial Organs, 2010
- Impact of Tubing Length on Hemodynamics in a Simulated Neonatal Extracorporeal Life Support CircuitArtificial Organs, 2010
- Comparison of Perfusion Quality in Hollow‐Fiber Membrane Oxygenators for Neonatal Extracorporeal Life SupportArtificial Organs, 2010
- Cardiopulmonary bypass with physiological flow and pressure curves: pulse is unnecessary!☆European Journal of Cardio-Thoracic Surgery, 2010
- Comparison of Two Types of Neonatal Extracorporeal Life Support Systems With Pulsatile and Nonpulsatile FlowArtificial Organs, 2009
- Impact of the Postpump Resistance on Pressure-Flow Waveform and Hemodynamic Energy Level in a Neonatal Pulsatile Centrifugal PumpASAIO Journal, 2009
- Extracorporeal Life Support Registry Report 2008: Neonatal and Pediatric Cardiac CasesASAIO Journal, 2009
- The Impact of Pump Settings on the Quality of PulsatilityASAIO Journal, 2009
- Comparison of Myocardial Loading Between Asynchronous Pulsatile and Nonpulsatile Percutaneous Extracorporeal Life SupportASAIO Journal, 2008
- Major Factors in the Controversy of Pulsatile Versus Nonpulsatile Flow During Acute and Chronic Cardiac SupportASAIO Journal, 2005