Prooxidant Effects of Maternal Smoking and Formula in Newborn Infants
- 1 January 1997
- journal article
- research article
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 24 (1), 68-74
- https://doi.org/10.1097/00005176-199701000-00016
Abstract
Background: The purpose of this study was to use the breath ethane test to determine if either maternal cigarette smoking, formula, and/or deficiency of the antioxidant nutrients vitamins A and E was associated with oxidant stress in newborn infants. The rationale for this study was: (1) our observation that cigarette smoking was a source of oxidant stress in pregnant women, suggesting that it could be a source of oxidant stress for infants exposed in utero; (2) formula was predicted to be prooxidant compared to colostrum, which contains several compounds with antioxidant activity in vitro; and (3) deficiencies of vitamins A and E have been shown to promote oxidant stress in experimental animals. Methods: Breath ethane, a volatile alkane produced by peroxide of n-3 fatty acids, was utilized as an index of oxidant stress status. Forty-five healthy full-term infants of the women mentioned above were studied at 18-24 h of age, after four to six feedings of breast milk (colostrum) or caseinbased infant formula. Relationships between infant breath ethane, maternal smoking, mode of infant nutrition, and serum concentrations of the antioxidant vitamins A and E of infants were examined. Results: The breath ethane of the entire group of infants whose mothers smoked (n = 19) was increased compared to values of infants whose mothers did not smoke (n = 26): 97 ± 16 versus 43 ± 9 pmol/kg/min, p < 0.03. When infants of mothers who smoked were eliminated from the analysis in order to study effects of nutrition alone, formula appeared to be prooxidant compared to breast milk. Breath ethane of formula-fed infants (n = 16) was 62 ± 13 versus 13 ± 4 pmol/kg/min for breast-fed infants (n = 10), p < 0.04. For the group as a whole, there was no correlation between infant breath ethane and serum concentrations of vitamins A and E. Conclusions: Exposure to maternal smoking in utero is prooxidant in newborn infants. Formula also has a prooxidant effect compared to colostrum in newborn infants not exposed to maternal smoking in utero. Further investigations will be necessary to explore the clinical consequences of these observations.Keywords
This publication has 28 references indexed in Scilit:
- Cigarette Smoking Is Pro-oxidant in Pregnant Women Regardless of Antioxidant Nutrient IntakeJournal of Nutritional & Environmental Medicine, 1995
- Breath ethane generation during clinical total body irradiation as a marker of oxygen-free-radical-mediated lipid peroxidation: A case studyFree Radical Biology & Medicine, 1994
- Breath ethane: A specific indicator of free-radical-mediated lipid peroxidation following reperfusion of the ischemic liverFree Radical Biology & Medicine, 1992
- Colostral AntioxidantsJournal of Pediatric Gastroenterology and Nutrition, 1992
- The reliability of self-reports of smoking and alcohol consumption by pregnant womenAddictive Behaviors, 1989
- Effects of Vitamin A and Its Analogs on Nonenzymatic Lipid Peroxidation in Rat Brain MitochondriaJournal of Neurochemistry, 1989
- Development of a method to monitor low molecular mass hydrocarbons in exhaled breath of man: preliminary evaluation of its interest for detecting a lipoperoxidation process in vivoClinica Chimica Acta; International Journal of Clinical Chemistry, 1987
- Furosemide and Vitamin EPediatric Clinics of North America, 1986
- Ethane expiration among smokers and non-smokers.Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 1985
- Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?Archives of Biochemistry and Biophysics, 1983