Relative effects of negative versus positive pressure ventilation depend on applied conditions
- 18 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Intensive Care Medicine
- Vol. 38 (5), 879-885
- https://doi.org/10.1007/s00134-012-2512-5
Abstract
Purpose Comparisons of negative versus positive pressure ventilation have imperfectly matched the pressure–time profile or the lung volume history, or have incompletely applied in vivo negative pressure to include the complete thoracic wall and abdomen. Hypothesis Negative pressure exerts the same pattern of lung distension as positive pressure when the pressure–time and volume history profiles are identical and the application of negative pressure is over the whole lung. Methods (1) In isolated (ex vivo) and (2) intact (in vivo) mouse lungs (n = 4/group) (sealed chamber enclosing either the whole lung or whole mouse except for external airway opening), identical and inverse-tidal, square-wave pressure–time profiles were obtained with positive and negative pressure ventilation. (3) Following an identical volume history, surfactant-depleted rabbits (n = 7) were randomly assigned to sustained, static equivalent positive versus negative pressures. (4) Surfactant-depleted anesthetized rabbits (n = 10) with identical volume histories were randomized to positive versus negative ventilation with identical pressure–time characteristics. Results Matched positive and negative pressure time profiles in ex vivo and in vivo mice resulted in identical tidal volumes. Identical (negative vs. positive) sustained static pressures resulted in similar PaO2 and end expiratory lung volumes. Positive and negative ventilation with identical volume histories and pressure time characteristics showed no difference in oxygenation or lung volumes. Historical comparisons suggested better oxygenation with negative pressure when the volume history was not identical. Conclusions These data do not support major biological differences between negative and positive pressure ventilation when waveforms and lung volume history are matched.This publication has 20 references indexed in Scilit:
- Lung-derived soluble mediators are pathogenic in ventilator-induced lung injuryAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2011
- Micromechanics of Alveolar EdemaAmerican Journal of Respiratory Cell and Molecular Biology, 2011
- Use of dynamic CT in acute respiratory distress syndrome (ARDS) with comparison of positive and negative pressure ventilationEuropean Radiology, 2008
- Negative-Pressure VentilationAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Adverse Ventilatory Strategy Causes Pulmonary-to-Systemic Translocation of EndotoxinAmerican Journal of Respiratory and Critical Care Medicine, 2000
- Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsideredEuropean Respiratory Journal, 1996
- Continuous negative extrathoracic pressure versus positive end‐expiratory pressure in piglets after saline lung lavagePediatric Pulmonology, 1994
- Role of Tidal Volume, FRC, and End-inspiratory Volume in the Development of Pulmonary Edema following Mechanical VentilationAmerican Review of Respiratory Disease, 1993
- Hemodynamic Effects of External Continuous Negative Pressure Ventilation Compared with Those of Continuous Positive Pressure Ventilation in Dogs with Acute Lung InjuryAmerican Review of Respiratory Disease, 1987
- Adult respiratory distress syndromeCritical Care Medicine, 1985