Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation
Open Access
- 28 February 2013
- journal article
- research article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2013, 1-9
- https://doi.org/10.1155/2013/919313
Abstract
Currently, the sole treatment option for patients with heart failure is transplantation. The battle of prolonging graft survival and modulating innate and adaptive immune responses is still being waged in the clinic and in research labs. The transcription factor Nrf2 controls major cell survival pathways and is central to moderating inflammation and immune responses. In this study the effect of Nrf2 levels in host recipient C57BL/6 mice on Balb/c allogeneic graft survival was examined. Importantly, Nrf2−/−recipient mice could not support the graft for longer than 7.5 days on average, whereas activation of Nrf2 by sulforaphane in Nrf2+/+hosts prolonged graft survival to 13 days. Several immune cells in the spleen of recipient mice were unchanged; however, CD11b+macrophages were significantly increased in Nrf2−/−mice. In addition, IL-17 mRNA levels were elevated in grafts transplanted into Nrf2−/−mice. Although Nrf2 appears to play a crucial role in graft survival, the exact mechanism is yet to be fully understood.Keywords
This publication has 25 references indexed in Scilit:
- Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicityCell Stress and Chaperones, 2012
- Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative ChallengeOxidative Medicine and Cellular Longevity, 2012
- Disruption of Type-I IFN Pathway Ameliorates Preservation Damage in Mouse Orthotopic Liver Transplantation via HO-1 Dependent MechanismAmerican Journal of Transplantation, 2012
- Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic CellsJournal of Biological Chemistry, 2012
- Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cellsInternational Journal of Molecular Medicine, 2012
- Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signalingFree Radical Biology & Medicine, 2012
- Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic NephropathyDiabetes, 2011
- Regeneration of infarcted myocardium with resveratrol‐modified cardiac stem cellsJournal of Cellular and Molecular Medicine, 2011
- Immunologic Basis of Graft Rejection and Tolerance Following Transplantation of Liver or Other Solid OrgansGastroenterology, 2011
- Targeting NRF2 signaling for cancer chemopreventionToxicology and Applied Pharmacology, 2009