Toward an information–motivation–behavioral skills model of microbicide adherence in clinical trials
- 14 June 2010
- journal article
- aidsimpact special-issue-2010
- Published by Taylor & Francis Ltd in AIDS Care
- Vol. 22 (8), 997-1005
- https://doi.org/10.1080/09540121003623719
Abstract
Unless optimal adherence in microbicide clinical trials is ensured, an efficacious microbicide may be rejected after trial completion, or development of a promising microbicide may be stopped, because low adherence rates create the illusion of poor efficacy. We provide a framework with which to conceptualize and improve microbicide adherence in clinical trials, supported by a critical review of the empirical literature. The information–motivation–behavioral skills (IMB) model of microbicide adherence conceptualizes microbicide adherence in clinical trials and highlights factors that can be addressed in behavioral interventions to increase adherence in such trials. This model asserts that microbicide adherence-related information, motivation, and behavioral skills are fundamental determinants of adherent microbicide utilization. Specifically, information consists of objective facts about microbicide use (e.g., administration and dosage) as well as heuristics that facilitate use (e.g., microbicides must be used with all partners). Motivation to adhere consists of attitudes toward personal use of microbicides (e.g., evaluating the consequences of using microbicides as good or pleasant) as well as social norms that support their use (e.g., beliefs that a sexual partner approves use of microbicides). Behavioral skills consist of objective skills necessary for microbicide adherence (e.g., the ability to apply the microbicide correctly and consistently). Empirical evidence concerning microbicide acceptability and adherence to spermicides, medication, and condom use regimens support the utility of this model for understanding and promoting microbicide adherence in clinical trials.Keywords
This publication has 57 references indexed in Scilit:
- Adherence and its Measurement in Phase 2/3 Microbicide TrialsAIDS and Behavior, 2009
- Protocol for SAMS (Support and Advice for Medication Study): A randomised controlled trial of an intervention to support patients with type 2 diabetes with adherence to medicationBMC Family Practice, 2008
- SAVVY Vaginal Gel (C31G) for Prevention of HIV Infection: A Randomized Controlled Trial in NigeriaPLOS ONE, 2008
- SAVVY® (C31G) Gel for Prevention of HIV infection in Women: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in GhanaPLOS ONE, 2007
- Willingness to use microbicides varies by race/ethnicity, experience with prevention products, and partner type.Health Psychology, 2007
- Assessing Microbicide Acceptability: A Comprehensive and Integrated ApproachAIDS and Behavior, 2007
- A Framework for Examining the Sustained Acceptability of MicrobicidesAIDS and Behavior, 2005
- Critical Issues in Contraceptive and STI Acceptability ResearchJournal of Social Issues, 2005
- Associations of Depression, Self-Esteem, and Substance Use with Sexual Risk among AdolescentsPreventive Medicine, 2001
- The importance of treatment acceptability to patientsInternational Journal of Psychiatry in Clinical Practice, 2000