Coronary Microcirculation in Health and Disease
- 21 January 1997
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 95 (2), 522-528
- https://doi.org/10.1161/01.cir.95.2.522
Abstract
This article summarizes a 2-day workshop on the coronary microcirculation held in Bethesda, Md, in September 1994 and sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health. The workshop explored a variety of topics pertaining to coronary microvascular physiology and pathophysiology. The latest methodologies that are being used to investigate the coronary microvasculature, including endoscopic microscopy of the intramural coronary microvasculature and micro–x-ray computerized tomography, were discussed. The most recent advances in the regulation of the coronary microcirculation—for example, myogenic and flow-dependent responses, KATP channels, and regional heterogeneity—were reported. The workshop touched on the relation of the microcirculation to clinically important conditions and offered recommendations for future research in this important area. Comparisons are made to recent advances in the peripheral circulation and current gaps in our knowledge concerning the coronary microcirculation. In recent years, research on the coronary microcirculation has made substantial advances, in part as a result of investigations in the peripheral microcirculation but also because of the application of unique methodologies. This research is providing new ways to investigate abnormalities of myocardial perfusion, an area of inquiry that until recently has been limited to examination of coronary pressure-flow relationships.Keywords
This publication has 82 references indexed in Scilit:
- Sympathetically mediated effects of mental stress on the cardiac microcirculation of patients with coronary artery diseaseThe American Journal of Cardiology, 1995
- Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.JCI Insight, 1995
- Reduced Coronary Vasodilator Function in Infarcted and Normal Myocardium after Myocardial InfarctionNew England Journal of Medicine, 1994
- Acute effect of cigarette smoking on the coronary circulation: Constriction of epicardial and resistance vesselsJournal of the American College of Cardiology, 1993
- Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.JCI Insight, 1993
- Dynamic limitation of coronary vasodilator reserve in patients with dilated cardiomyopathy and chest painJournal of the American College of Cardiology, 1987
- Three-Dimensional X-Ray MicrotomographyScience, 1987
- Transmural myocardial perfusionProgress in Cardiovascular Diseases, 1987
- Intramural (“small vessel”) coronary artery disease in hypertrophic cardiomyopathyJournal of the American College of Cardiology, 1986
- Intestinal microvascular adaptation during maturation of spontaneously hypertensive rats.Hypertension, 1983