Selective deficiency of pancreatic amylase.
Open Access
- 1 May 1991
- Vol. 32 (5), 546-548
- https://doi.org/10.1136/gut.32.5.546
Abstract
Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase activity in serum or duodenal aspirates, or both, does not necessarily represent chronic exocrine pancreatic disease such as chronic pancreatitis, carcinoma of the pancreas, or cystic fibrosis but may be an isolated finding. In one of our patients a familial occurrence was shown, indicating a congenital deficiency.Keywords
This publication has 27 references indexed in Scilit:
- Familial occurrence of diminished pancreatic amylase in serum--a "silent" Amy-2 allelic variant?Clinical Chemistry, 1988
- Effect of short- and long-term alcohol feeding in rats on pancreatic enzyme content and enzyme secretion in isolated pancreatic lobules in vitroInternational journal of pancreatology, 1986
- [Normal human pancreatic secretion in relation to age].1970
- Trypsinogen Deficiency DiseaseArchives of Pediatrics & Adolescent Medicine, 1967
- [Congenital absence of pancreatic lipase].1966
- Congenital Pancreatic Lipase DeficiencyArchives of Disease in Childhood, 1964
- Pancreatic Exocrine Function in Neoplastic and Inflammatory Disease; A Simple and Reliable New TestGastroenterology, 1962
- A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.1959
- Selective pancreatic deficiency, absent amylase, diminished trypsin, and normal lipase.1951
- PANCREATIC FUNCTION AND DISEASE IN EARLY LIFE. I. PANCREATIC ENZYME ACTIVITY AND THE CELIAC SYNDROME 1JCI Insight, 1943