Insights into battles between Mycobacterium tuberculosis and macrophages
Open Access
- 18 June 2014
- journal article
- review article
- Published by Oxford University Press (OUP) in Protein & Cell
- Vol. 5 (10), 728-736
- https://doi.org/10.1007/s13238-014-0077-5
Abstract
As the first line of immune defense for Mycobacterium tuberculosis (Mtb), macrophages also provide a major habitat for Mtb to reside in the host for years. The battles between Mtb and macrophages have been constant since ancient times. Triggered upon Mtb infection, multiple cellular pathways in macrophages are activated to initiate a tailored immune response toward the invading pathogen and regulate the cellular fates of the host as well. Toll-like receptors (TLRs) expressed on macrophages can recognize pathogen-associated-molecular patterns (PAMPs) on Mtb and mediate the production of immune-regulatory cytokines such as tumor necrosis factor (TNF) and type I Interferons (IFNs). In addition, Vitamin D receptor (VDR) and Vitamin D-1-hydroxylase are up-regulated in Mtb-infected macrophages, by which Vitamin D participates in innate immune responses. The signaling pathways that involve TNF, type I IFNs and Vitamin D are inter-connected, which play critical roles in the regulation of necroptosis, apoptosis, and autophagy of the infected macrophages. This review article summarizes current knowledge about the interactions between Mtb and macrophages, focusing on cellular fates of the Mtb-infected macrophages and the regulatory molecules and cellular pathways involved in those processes.Keywords
This publication has 66 references indexed in Scilit:
- Expression of TNF-Alpha-Dependent Apoptosis-Related Genes in the Peripheral Blood of Malagasy Subjects with TuberculosisPLOS ONE, 2013
- The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death PathwaysCell, 2012
- Lower levels of interleukin-12 precede the development of tuberculosis among HIV-infected womenCytokine, 2011
- Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human MacrophagesScience Translational Medicine, 2011
- Complex Inhibitory Effects of Nitric Oxide on AutophagyMolecular Cell, 2011
- Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosisMucosal Immunology, 2011
- Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?Nature Reviews Microbiology, 2010
- Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signallingCellular Microbiology, 2010
- Expression of Cathelicidin LL-37 duringMycobacterium tuberculosisInfection in Human Alveolar Macrophages, Monocytes, Neutrophils, and Epithelial CellsInfection and Immunity, 2008
- Host Innate Immune Response to Mycobacterium tuberculosisJournal of Clinical Immunology, 2007