Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Top Cited Papers
- 9 December 2011
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 334 (6061), 1420-1424
- https://doi.org/10.1126/science.1213214
Abstract
Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches.Keywords
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